
Research has found that three diet drugs recommended for long-term use result in minimal weight loss and carry some serious side effects.
Though most users of the drugs remained overweight, experts said the drugs could help curb the dangers of obesity by reducing rates of heart disease, diabetes and other health problems.
In a paper published Friday in the British Medical Journal, researchers in Canada and Brazil analyzed existing data on three popular weight-loss drugs: orlistat, or Xenical; sibutramine, known as Meridia in the United States and Reductil in Europe; and rimonabant, or Accomplia.
Scientists found that patients on the drugs -- men and women between 45 and 50 years old who weighed about 220 pounds and had a body mass index of about 35 -- lost less than 11 pounds on average. The study participants used the drugs for periods of between one and four years.
Medical studdies found:
Patients (10,631 people) who took Orlistat which works by preventing fat digestion helped people lose only 6.6 pounds on average. The drug also reduced diabetes, improved cholestoral levels and blood pressure. As for the side effects up to 30 percent of patients had unpleasant digestive and intestinal side effects.
Participants (2,623 people) who took sibutramine lost about 9 pounds on average and improved cholestoral levels. The side effects inluded raised blood pressure and pulse rates, insomnia and nausea.
Participants who took rimonabant (6,365 people) lost an average of about 11 pounds. The drug improved their blood pressure and cholesterol levels. The risk of mood disorders increased in 6 percent of patients. Another published study found that rimonabant raised the risk of psychiatric problems such as depression and anxiety
Both sibutramine and rimonabant work by interrupting nerve signals in the brain.
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